›› 2016, Vol. 34 ›› Issue (7): 506-.doi: 10.3969 j.issn.1000-3606.2016.07.007

Previous Articles     Next Articles

Clinical analysis of the risk factors of intracranial hemorrhage in 485 full-term small for gestational age infants

ZHANG Zhi, LU Jiangyi, LI Luquan   

  1. Neonatal Diagnosis and Treatment Center, Children’s Hospital of Chongqing Medical University; National Demonstration Base of Standardized Training Base for Resident Physicians; Key Laboratory of Pediatrics in Chongqing; Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China
  • Received:2016-07-15 Online:2016-07-15 Published:2016-07-15

Abstract: Objective To explore the types of intracranial hemorrhage (ICH) and its risk factors in full-term small
for gestational age (SGA) infants. Methods The clinical data of 485 full-term SGA infants were retrospectively analyzed. Perinatal period factors, complications prior to diagnosis of intracranial hemorrhage, cranial imaging examination, and behavioral neurological assessment were analyzed. Results In 485 cases of full-term SGA infants, there were 83 cases (17.1%) of ICH, in whom  68 cases (81.9%) had periventricular hemorrhage or intraventricular hemorrhage with 15 cases (22.1%) of grade Ⅰ, 50 cases (73.5%) of grade Ⅱ, 1 case (1.5%) of grade Ⅲ and 2 cases (2.9%) of grade Ⅳ. The remaining 15 cases were mainly subarachnoid hemorrhage (60%, 9/15). Univariate analysis showed that the incidences of amniotic fluid contamination, neonatal scleredema and patent ductus arteriosus were higher in ICH infants than those in non-ICH infants (all P < 0.05). Logistic analysis showed that amniotic fluid contamination, neonatal scleredema, and patent ductus arteriosus were the independent risk factors of ICH. Conclusions The types of ICH in full-term SGA infants was periventricular hemorrhage and intraventricular hemorrhage. Amniotic fluid contamination, neonatal scleredema, and patent ductus arteriosus were the independent risk factors of ICH.